Over-the-counter (OTC) topical acne treatments are medications applied directly to the skin. Benzoyl peroxide, a common ingredient found in OTC acne medications, can be used during pregnancy as well as prescription topical clindamycin. These OTC topical acne products do not appear to increase the risk for birth defects in pregnancy as so little of the medication gets through the skin to the baby. It is safe to breast feed while using these products, too, as long as the product does not come into contact with the baby. See your dermatologist to discuss your options for control of acne during pregnancy.