Decadron steroid cancer

Side effects are minimized by taking the lowest doses possible (that still yields positive results) and following doctor's orders. It is important to avoid self-regulation of the dosage, either by adding more or stopping the drug without a schedule. After prolonged use, steroids must be gradually reduced to permit the adrenal glands to resume natural cortisol production. Eliminating doses too quickly can result in glucocorticoid withdrawal symptoms, worsening of underlying inflammatory disease (rebound effect), or rarely, adrenal crisis (a life-threatening state caused by insufficient levels of adrenal steroids).

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor immediately if any of these unlikely but serious side effects occur: signs of infection (., fever, persistent sore throat), bone/joint pain, increased thirst/urination, fast/slow/irregular heartbeat, eye pain/pressure, vision problems, heartburn, black stools, vomit that looks like coffee grounds, puffy face, swelling of the ankles/feet, stomach/abdominal pain, pain/redness/swelling of arms/legs, tiredness, mental/mood changes (., depression, mood swings, agitation), unusual hair/skin growth, muscle pain/cramps, weakness, easy bruising/bleeding, slow wound healing, thinning skin, seizures. A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. Read the entire patient information overview for Decadron (Dexamethasone )

Author: Charles Davis, MD, PhD, Research Director, Professor of Emergency Medicine, Department of Surgery, Division of Emergency Medicine, University of Texas Health Science Center at San Antonio.

Coauthor(s): Nitin Tandon, MD, Staff Physician, Department of Surgery, Division of Neurosurgery, University of Texas Health Science Center at San Antonio.

Editors: Brian F Chinnock, MD, Assistant Professor, Department of Emergency Medicine, Texas Tech University Health Sciences Center at El Paso; Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine; Jerry Balentine, DO, Professor of Emergency Medicine, New York College of Osteopathic Medicine; Medical Director, Saint Barnabas Hospital.
 

The dosing of dexamethasone is somewhat controversial. Depending on the severity of the lesion, investigators have recommended an intravenous bolus dose (loading dose) ranging from 16 to 100 mg, followed by 4 to 24 mg given intravenously four times daily for three days; tapering is accomplished by reducing the dosage by one third every three days during radiotherapy. 19 High-dose dexamethasone therapy with a bolus dose of 96 to 100 mg has side effects that outweigh the benefits over use of a 16-mg loading dose with a 14-day taper. 20 , 21 Furthermore, the 16-mg regimen does not have a significant difference in the number of patients having pain, bladder dysfunction, or inability to walk. 20 , 21

Decadron steroid cancer

decadron steroid cancer

The dosing of dexamethasone is somewhat controversial. Depending on the severity of the lesion, investigators have recommended an intravenous bolus dose (loading dose) ranging from 16 to 100 mg, followed by 4 to 24 mg given intravenously four times daily for three days; tapering is accomplished by reducing the dosage by one third every three days during radiotherapy. 19 High-dose dexamethasone therapy with a bolus dose of 96 to 100 mg has side effects that outweigh the benefits over use of a 16-mg loading dose with a 14-day taper. 20 , 21 Furthermore, the 16-mg regimen does not have a significant difference in the number of patients having pain, bladder dysfunction, or inability to walk. 20 , 21

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