Gynecomastia is a common adverse effect of bicalutamide (Casodex) therapy that may prompt some men to discontinue prostate cancer treatment. Tamoxifen has been recommended as a preventive agent for gynecomastia in these patients. A double-blind study of 282 men randomized to receive 20 mg of tamoxifen once per day with bicalutamide or bicalutamide alone found that after six months, gynecomastia and breast pain were significantly reduced in men who received tamoxifen ( versus percent in the control group). 41 An Italian randomized controlled trial of 80 participants also found that 20 mg of tamoxifen once per week is as effective as 20 mg once per day. 42
Individuals who have cirrhosis or chronic liver disease may develop gynecomastia for several reasons. Cirrhotics tend to have increased secretion of the androgenic hormone androstenedione from the adrenal glands, increased conversion of this hormone into various types of estrogen,  and increased levels of SHBG, which leads to decreased blood levels of free testosterone.  Approximately 10–40% of individuals with Graves' disease (a common form of hyperthyroidism ) experience gynecomastia.  Increased conversion of testosterone to estrogen by increased aromatase activity,  increased levels of SHBG and increased production of testosterone and estradiol by the testes due to elevated levels of LH cause the gynecomastia. Proper treatment of the hyperthyroidism can lead to the resolution of the gynecomastia. 
As a mild steroid, while most men who supplement will use it while dieting they will still need to take a fairly large amount to gain any positive effect. If you supplement with oral Primo you will need even more per week than if you choose injectable and as both are very expensive; as you can guess this cost will add up very fast. Most men who try Primobolan and who are disappointed on the basis of no results are usually found lacking simply because they didn’t take enough; for example, an average man will need approximately 500mg per week of injectable Primo to receive a benefit and he will need to do so for at least 8 weeks . Yes, you can absolutely take more and for a longer period of time but if you do be prepared to feel your wallet get a whole lot lighter.
You may have already guessed, while Primobolan can be used by men if we were to recommend it to anyone it would be the female performance enhancer first; not only because it will be tolerated so well by her but because she will not need nearly as much making it all the more affordable and feasible. Again, injectable Primo will prove to be best but to ensure safety and protection against virilization is in place most women will not want to exceed 6 weeks of use max with 4 weeks of use generally being the minimal time frame. For women who want more they can absolutely run another course but it is advised that 4 weeks of discontinued use be held to before another course begins. For the average woman most will find 100mg per week to be sufficient; you can go higher but the higher you go the greater the risk. You may need to play with the dosing a little bit but 100mg is a good place to start and 2 injections per week of 50mg each is just about perfect.