Steroid myopathy emg findings

Anderson and colleagues from St Thomas' Hospital , London, were the first to mention a case with possible clinical findings of LEMS in 1953, [9] but Lambert, Eaton, and Rooke at the Mayo Clinic were the first physicians to substantially describe the clinical and electrophysiological findings of the disease in 1956. [10] [11] In 1972, the clustering of LEMS with other autoimmune diseases led to the hypothesis that it was caused by autoimmunity. [12] Studies in the 1980s confirmed the autoimmune nature, [5] and research in the 1990s demonstrated the link with antibodies against P/Q-type voltage-gated calcium channels. [1] [13]

In combination, NCSs and a needle EMG examination may be most helpful when performed several weeks after the injury has occurred. However, NCSs are often useful acutely after nerve injury, for example, if there is concern that a nerve has been severed. In fact, if studies are delayed, the opportunity to precisely identify the region of injury or to intervene may be lost. In some cases, even needle EMG testing performed immediately after a nerve injury may demonstrate abnormal motor unit action potential (MUAP) recruitment and/or provide baseline information that can be helpful to document preexisting conditions, date the injury, or serve as a baseline for comparison with later studies.

Dr. Salter completed medical school and a Master of Science in Human Biodynamics at McMaster University.  She completed her specialty training in Physical Medicine and Rehabilitation at the University of Manitoba in 2012.  Dr. Salter is certified in Electrodiagnostic Medicine by the Canadian Society of Clinical Neurophysiologists.  She is an assistant professor with the University of Manitoba, Undergraduate Program Director for Physical Medicine and Rehabilitation for the University of Manitoba Medical School and Service Chief for the Acquired Brain Injury Program at Riverview Health Centre. 
 

If the neurologic examination is unrevealing, a more general physical examination, searching for extramuscular signs, is warranted ( Table 6 5 , 7 – 15 , 17 , 18 , 21 , 24 – 27 , 34 , 36 , 38 ) . Mental status testing may reveal changes suggestive of a myopathy-inducing electrolyte disorder (calcium or magnesium) or an arrest of mental development as occurs in genetic myopathies. 25 , 29 The cardiovascular assessment may elicit changes consistent with a cardiomyopathy—a nonspecific consequence of many myopathy-inducing disorders—or a pericarditis, as occurs with some of the infectious and rheumatologic causes of muscle weakness. 5 , 7 , 8 , 9 , 18 , 21 , 24 , 25 , 29 , 36 , 38

Polymyositis and the associated inflammatory myopathies have an associated increased risk of malignancy . [3] The features they found associated with an increased risk of cancer was older age, age greater than 45, male sex, dysphagia, cutaneous necrosis, cutaneous vasculitis , rapid onset of myositis (<4 weeks), elevated creatine kinase , higher erythrocyte sedimentation rate and higher C-reactive protein levels. Several factors were associated with lower-than-average risk, including the presence of ILD, arthritis / arthralgia , Raynaud's syndrome , or anti-Jo-1 antibody. [3] The malignancies that are associated are nasopharyngeal cancer , lung cancer , non-Hodgkin's lymphoma and bladder cancer , amongst others. [4]

Steroid myopathy emg findings

steroid myopathy emg findings

If the neurologic examination is unrevealing, a more general physical examination, searching for extramuscular signs, is warranted ( Table 6 5 , 7 – 15 , 17 , 18 , 21 , 24 – 27 , 34 , 36 , 38 ) . Mental status testing may reveal changes suggestive of a myopathy-inducing electrolyte disorder (calcium or magnesium) or an arrest of mental development as occurs in genetic myopathies. 25 , 29 The cardiovascular assessment may elicit changes consistent with a cardiomyopathy—a nonspecific consequence of many myopathy-inducing disorders—or a pericarditis, as occurs with some of the infectious and rheumatologic causes of muscle weakness. 5 , 7 , 8 , 9 , 18 , 21 , 24 , 25 , 29 , 36 , 38

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